
Wen also provided the voice for the title character in Disney's animated movie Mulan, and its sequel Mulan II, as well as reprising her role in the Square Enix/Disney video game Kingdom Hearts II, Aki Ross in the computer animated film Final Fantasy: The Spirits Within, and Detective Ellen Yin in the animated series The Batman. She also appeared in a supporting role on the comedy series The Single Guy which starred Jonathan Silverman. Wen starred in the movie version of Amy Tan's novel The Joy Luck Club and played Chun-Li in Street Fighter. Five years later, she was invited back as a series regular in Season 6 and remained on the show until midway through Season 11. She first guest starred during the first season. Jing-Mei "Deb" Chen on the NBC drama series ER. She graduated with a Bachelor of Fine Arts in Drama from Carnegie Mellon University.

During her teen years she worked at her stepfather's family's restaurant called Chinatown Inn in downtown Pittsburgh's Chinatown, which her family still runs today.

Wen attended high school in the Pittsburgh suburb of Mt. Wen was born on Coloane Island, Macau, to Cantonese parents and lived in Hong Kong with her mother (then working as a nurse) and older brother, and later moved to the US as a child with her mother, older brother, and stepfather first to Queens, New York and then to the Pittsburgh area.
